Aplikasyon pvp nan rechech ak devlopman pharmaceutics (2)
3. Itilize kom yon konpayi asirans nan konpayi asirans dispesyon solid
Amelyore absopsyon nan megman idrosolubl Dwog nan ko a te toujou yon sije cho. Pou reyalize objektif sa a, konsidere ogmante solubility li yo ak pousantaj metakaolinite. Yon dispesyon solid se dispese megman idrosolubl Dwog nan molekile, koloidal, microcrystalline, oswa amorphe eta li te fe soti nan yon materyel dlo-idrosolubl, ki ka siyifikativman ogmante pousantaj metakaolinite la epi fe li plis pedi. PVP se yon konpayi souvan itilize pou vejetasyon solid dispesyon. Ekspe prepare carvedilol solid dispesyon nan etid comparative pou detemine ke pousantaj metakaolinite nan carvedilol solid dispesyon nan dives kalite pwoposyon ak poud orijinal la nan Dwog la yo siyifikativman diferan (P<0.05) or="" extremely="" significant="">< 0.001),="" the="" dissolution="" rate="" is="" significantly="" greater="" than="" the="" original="" powder="" of="" the="" drug,="" and="" the="" two="" solid="" dispersions="" of="" car-peg-6000="" and="" car-pvp="" both="" show="" the="" same="" result:="" as="" the="" amount="" of="" carrier="" increases,="" the="" dissolution="" speeds="" up,="" but="" as="" the="" number="" of="" carrier="" increases,="" the="" increase="" of="" dissolution="" rate="" slows="" down.="" the="" dissolution="" effect="" of="" pvp="" as="" a="" carrier="" of="" carvedilol="" is="" better="" than="" that="" of="" peg-6000.="" in="" another="" aging="" test,="" car-peg-6000="" is="" easier="" to="" age="" than="" car-pvp.="" therefore,="" the="" author="" believes="" that="" pvp="" is="" used="" as="" a="" solid="" dispersion="" of="" carvedilol.="" the="" carrier="" is="" better.="" both="" peg-6000="" and="" pvp="" are="" commonly="" used="" solid="" dispersion="" carriers,="" which="" basically="" do="" not="" interfere="" with="" the="" determination="" of="" the="" main="" drug.="" after="" carvedilol="" is="" treated="" by="" solid="" dispersion="" technology,="" it="" can="" significantly="" increase="" the="" dissolution="" rate="" in="" vitro,="" thereby="" increasing="" the="" bioavailability="" in="" vivo,="" providing="" an="" effective="" way="" for="" carvedilol="" to="" make="" high-efficiency="">
4. Itilize kom Pu manbran materyel kouch
Anjeneral, PVP ak espesifikasyon ka itilize kom yon materyel fim medsin-fome oswa konbine avek lot materyel fim paske nan fleksibilite ideyal li yo. Pratik la te pwouve ke PVP ka itilize nan pwosesis la kouch fim nan tou de dlo ak sistem solvan oganik. Avantaj li yo nan kouch yo se: li ka amelyore adezyon an nan fim nan sifas la, amelyore dispebilite nan Lakes oswa koloran, epi yo ka itilize kom yon fim plasticizer. Li ka chanje tan an dezentegrasyon nan fim nan ki baze sou materyel idrofob. Konsantrasyon an abityel pou kouch se 0.5%---5%. Koulye a, gen PVP / VA seri pwodwi espesyalman itilize kom materyel fim-fome. Yo copolymers nan VP (vinil pyrrolidone) ak fe (vinil D').